Longevity Consortium

What drives human longevity and healthy aging?

Discovering the factors that influence lifespan and how they can be targeted for therapeutic intervention.

Integrative Analysis Core

The Integrated Analysis Core (IAC) supports and promotes integrated analyses across the 5 Longevity Consortium (LC) projects using both available and novel resources and data analysis methods.

Human Longevity Association

Human Longevity Associations leverages LC legacy data with external sources to uncover how various factors shape longevity and age-related health trends.

Cross Species and Evolutionary Biology

Evolutionary forces have generated enormous amounts of molecular and clinically relevant phenotypic diversity across species, with several independent mammalian lineages evolving long life- and health-spans.

Extreme Longevity and Alzheimer’s

Extreme longevity (EL) is influenced by combinations of gene variants that may hold the explanation of why and how many centenarians and their offspring reach extreme old ages with good cognitive function and delay or even escape Alzheimer’s disease and related dementias (ADRD).

Drug Targeting, Testing, and Development

This project aims to discover drugs that can slow aging and extend lifespan by postponing age-dependent changes that impair health. The chemoinformatics group (Girke team) develops new strategies for identifying drugs and targets likely to slow aging.

Cell Biology and Functional Analysis

The mechanisms that drive resiliency or, conversely, rapid decline, remain unclear. Models of human aging, longevity, and resilience to disease that allow for the functional testing of potential interventions are virtually non-existent.